Cancer corruption factor alpha (TNF-α) is created by neutrophils, initiated lymphocytes, macrophages, NK cells, LAK cells, astrocytes endothelial cells, smooth muscle cells and a few changed cells. Mouse TNF-α happens as a layer moored structure. The normally happening type of TNF-α is glycosylated, yet non-glycosylated recombinant TNF-α has similar organic movement. The organically dynamic local type of TNF-α is supposedly a trimer. Human and mouse TNF-α show roughly 79% homology at the amino corrosive level and crossreactivity between the two species.
Cytokine Profiling Antibody Array
Cytokine Profiling Antibody Array highlights 310 novel antibodies for profiling cytokines, chemokines and related biomarkers in human cells, tissues, serum or culture media. Each bundle contains two indistinguishable exhibit slides for investigating two examples, for example, a control test and a treatment test.
CYTOKINE PROFILING ANTIBODY ARRAY
Cytokine Profiling Antibody Array is a high-throughput ELISA based immunizer cluster for protein articulation profiling of cytokines, chemokines and related biomarkers. The exhibit is intended for contrasting typical examples with treated or infected examples, and recognizing applicant biomarkers.
KEY FEATURES
- 310 cytokine related antibodies; 6 reproduces per counter acting agent
- Subjective/semi-quantitative protein articulation profiling of cytokines and related biomarkers
- Antibodies covalently immobilized on 3D polymer covered glass slide
- Fluorescent discovery.
Neutralizer Cloning and Sequencing
Our counter acting agent sequencing administration is speedy and solid, and is presented as an independent item or part of a neutralizer acculturation bundle. With our fulfillment ensure, you are guaranteed to get dependable outcomes with a full report of the agreement variable pieces of weighty chain (VH) and light chain (VL), CDR and structure assurance, and cDNA develop.
Fast Custom Monoclonal Antibody (mAb) Hybridoma Production
Our neutralizer age administration utilizes an assortment of advancements including hybridoma and library screening. Working intimately with you, we give on plan and articulation conference on mAb designing and assembling to meet your particular prerequisites. Each venture is isolated into three stages: antigen vaccination and screening, combination screening, and cloning and creation. Ordinary venture completion time is 8-12 weeks.
Neutralizer Isotype/Class/Subclass Switching
The neutralizer isotype exchanging process includes supplanting just the steady locale of an immunizer while keeping up with the variable areas, hence saving the explicitness of your counter acting agent. Immune response class exchanging doesn’t influence antigen explicitness, yet holds antigen fondness and permits connection with various effector atoms. Utilizing our exclusive innovation and in-house aptitude, we can adjust immune response’s isotype from any species to human IgG isotypes.
Recombinant Antibody (Chimeric Antibody) Construction and Production.
Oak BioSciences has fostered a restrictive innovation for quick creation of cell lines communicating full length fanciful antibodies, permitting clients to get antibodies planned and delivered with explicit articulation and portrayal necessities. Illusory antibodies contain variable areas, sequenced from your hybridoma cell line, which can be joined with any steady space.
Single-Chain Variable Fragment (scFv-Fc) Construction and Production.
ScFv’s deal various benefits over monoclonal antibodies as medication transporters to cancers, for example, more noteworthy growth infiltration, low kidney take-up, quick blood leeway, and more positive reaction from human resistant framework. Our administration gives scFv development through three distinct strategies:
- Produced from Synthetic DNA
- Produced from Monoclonal Cell Line
- Manufactured from Accession Number
In-Vivo High Efficiency Biotinylated Single-Chain Variable Fragment (scFv) Production
Through the high particularity and fondness of Biotin-Streptavidin/Avidin connection, biotinylated immune response sections are of extraordinary interest because of their appropriateness and dependability in different computerized protein measures. Utilizing our exclusive procedures, we can get a scFv biotinylation pace of up to 100 percent in vivo.
Immunizer Library Construction
Oak BioSciences has practical experience in the development of different neutralizer libraries, including natural scFv, Fab, VHH and other altered designs, utilizing human plasma cells from solid contributors and patients, and splenocytes from either gullible or vaccinated mice, or different sources.
Phage Display Screening from Combinatorial Libraries
Our researchers have broad involvement with the screening of phage show libraries. We can accomplish a fondness of 10-7~10-9 for scFv/Fab antibodies by leading library screening and prospecting 4 cycles.
Immunizer Humanization
Oak BioSciences gives a restrictive counter acting agent adaptation administration. Utilizing our three dimensional displaying and V-combination Cloning advancements, the arrangements of counter acting agent variable spaces, which decide its limiting explicitness, can be consolidated into human giver successions, accordingly making a board of full length refined antibodies and high liking antibodies for your requirements. Through panning our site-explicit planned phage show libraries, we could improve proclivity from 10 to multiple times.
Immunizer Affinity Maturation Service
Our in vitro liking development administration is intended for improvement of antibodies, neutralizer sections or other peptide atoms, for example, immune response mimetics. With a couple of rounds of transformation and determination, liking for counter acting agent pieces can increment 10-1,000 folds.
Stable Cell Line Development for Monoclonal Antibody (mAb) Production
Oak BioSciences can assist you with creating stable mammalian cell line from your monoclonal mouse cell lines or basically from a peptide/DNA arrangement or promotion number. We offer a decision of in-house or industrially accessible articulation vectors.
Immune response Epitope Mapping
Phage libraries showing a huge number of peptides with randomized groupings are incredibly helpful instruments for planning immune response epitopes.
Human hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha) ELISA Kit, 96 tests, Quantitative |
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| 100-530-HIF | Alpha Diagnostics | 1 Kit | 854.4 EUR |
Human Hypoxia Inducible Factor 1 Alpha (HIF-1a) CLIA Kit |
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| abx195749-96tests | Abbexa | 96 tests | 990 EUR |
Mouse Hypoxia Inducible Factor 1 Alpha (HIF-1a) CLIA Kit |
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| abx195750-96tests | Abbexa | 96 tests | 990 EUR |
Rat Hypoxia Inducible Factor 1 Alpha (HIF-1a) CLIA Kit |
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| abx195751-96tests | Abbexa | 96 tests | 990 EUR |
Human hypoxia-inducible factor 1?,HIF-1? ELISA Kit |
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| 201-12-0423 | SunredBio | 96 tests | 528 EUR |
Human hypoxia-inducible factor 1α(HIF-1α) ELISA kit |
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| 1-CSB-E12112h | Cusabio |
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Human hypoxia-inducible factor 2(HIF-2) ELISA kit |
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| 1-CSB-E12113h | Cusabio |
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HIF-2alpha Hypoxia-inducible factor 2 alpha, Human |
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| LF-P0420 | Abfrontier | 0.5mg | 242.4 EUR |
Procine hypoxia-inducible factor 1α, HIF-1α ELISA Kit |
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| 1-CSB-E11288p | Cusabio |
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Rat hypoxia-inducible factor 1α, HIF-1α ELISA Kit |
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| 1-CSB-E08540r | Cusabio |
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Mouse hypoxia-inducible factor 1α, HIF-1α ELISA Kit |
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| 1-CSB-E08541m | Cusabio |
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Human hypoxia-inducible factor 1α(HIF-1α) ELISA kit |
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| CSB-E12112h-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Human hypoxia-inducible factor 2(HIF-2) ELISA kit |
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| CSB-E12113h-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Human hypoxia-inducible factor 1α,HIF-1α ELISA Kit |
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| CN-03547H1 | ChemNorm | 96T | 573.6 EUR |
Human hypoxia-inducible factor 1α,HIF-1α ELISA Kit |
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| CN-03547H2 | ChemNorm | 48T | 394.8 EUR |
Human hypoxia-inducible factor 1α(HIF-1α)ELISA Kit |
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| GA-E0439HM-48T | GenAsia Biotech | 48T | 346.8 EUR |
Human hypoxia-inducible factor 1α(HIF-1α)ELISA Kit |
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| GA-E0439HM-96T | GenAsia Biotech | 96T | 559.2 EUR |
Human hypoxia-inducible factor 1α(HIF-1α)ELISA Kit |
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| QY-E03809 | Qayee Biotechnology | 96T | 472.8 EUR |
CLIA kit for Human HIF-1? (Hypoxia Inducible Factor 1 Alpha) |
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| E-CL-H0832 | Elabscience Biotech | 1 plate of 96 wells | 700.8 EUR |
Oak Biosciences has made irregular peptide libraries by embedding short manufactured oligonucleotides with a totally randomized succession normally at the designed 5′- finish of gIII quality.